Knee osteoarthritis affects 250 million people worldwide. It involves the degeneration of knee joint cartilage and the underlying bone. Patients can experience severe pain accompanied by a decreased range of motion and reduced mobility. Osteoarthritis has no cure, so treatment involves reducing and managing pain, or surgical interventions such as a total joint replacement. Regenerative medicine can offer a new treatment, for example through a bioengineered joint replacement. The RegMed XB partners are coming together to take the first steps towards a bioengineered joint as a treatment and possible cure for osteoarthritis of the knee.