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The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule
PUBLISHED
05 Oct 2021

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The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule

Jasia King, Silvia M. Mihaila, Sabbir Ahmed, Roman Truckenmüller, Stefan Giselbrecht, Rosalinde Masereeuw and Aurélie Carlier from MERLN Institute for Technology-Inspires Medicine, Maastricht University and Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, have published the article “The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study”

Schematic of the parameter-fitting model based on data from IS cellular uptake experiments with four reacting species

Image from King et al., 2021 article: "The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study" 

We would like to congratulate the authors for this publication and especially for their work within RegMed XB’s Kidney Moonshot, which aims to develop a sustainable cure for kidney-related chronic diseases using regenerative medicine.

To learn more on what promises to be a new step in kidney-related research, read the full article by clicking below.

Read the full article

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